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The short answer for most people is yes, but with careful monitoring

In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight

Desiring to be one of the largest competitors ever, he had his first overall win at the 1993 Iron Bodies Invitational

During clinical trials, it was found that similar exposure is achieved with subcutaneous administration of semaglutide in the abdomen, thigh, or upper arm