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Dr Riccardo De Giorgi, an expert in adult psychiatry at the University of Oxford and the lead author of the study, said the results suggest the use of the injections "could extend beyond managing diabetes, potentially offering unexpected benefits in the treatment and prevention of cognitive decline and substance misuse"

Curcumin, at doses that achieve a hormetic effect (e.g., 10 mg/L or approximately 28 M in vitro ), can enhance antioxidant defense by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, upregulating glutathione (GSH) metabolism, and inducing glutathione S-transferase (GST) activity, particularly isoforms involved in detoxifying lipid peroxidation products such as 4-hydroxynonenal (4-HNE)

M.HamzahH.IsmailA

used extensively to validate the melanocortin hypothesis of body weight regulation