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Ischemiareperfusion notably increased oxidative stress, apoptosis, and inflammatory markers, as shown by higher levels of malondialdehyde, caspase-3, TNF-, and IL-6 ( p 0.05, and homogeneity of variance using Bartletts test before the ANOVA test

Approximately 15% of couples worldwide experience infertility, and 2.5%12% of men of reproductive age are estimated to be infertile, with marked regional variations (Atmoko et al., 2024)

Shift workers and frequent travelers Circadian rhythm disruption from rotating shifts or frequent time zone changes creates a specific type of sleep problem that melatonin alone handles poorly

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