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However, iron overload in patients with hemochromatosis results in excessive PS externalization and calpain activation in RBCs [83]
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When should injectable glutathione still be considered
At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)
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