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Some preclinical studies have shown a potential link between DPP-4 inhibition and autophagy induction
Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)
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In the last decade and a half, the discovery of AntagoMiRs, synthetic oligonucleotides with an anti-sense sequence explicitly targeting a particular miRNA, has been a significant breakthrough
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