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The external membrane comprises a complex phospholipid bilayer, which is composed of scattered cholesterol, sphingolipids, and unsaturated acyl acids (Komatsuya et al., 2020)

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( Figure 5 ) Briefly, SGLT2i inhibits the SGLT receptors in the proximal tubule, which inhibits the reabsorption of glucose from primary urine, resulting in glycosuria and a decrease in HbA1c and fasting glucose levels (34)