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3) came from studies in which human fibroblasts were reprogrammed into neurons, then treated with Epitalon [53]
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7 IL-1 and elastase released by neutrophils exacerbate cartilage damage, whereas their derived extracellular vesicles enhance cartilage protection Neutrophils are the first immune cells recruited during cartilage damage in osteoarthritis (OA)
We then examine several compounds capable of promoting NRF2 activity thereby inducing cytoprotective effects, and which are currently in different stages of clinical development for many pathologies, including neurodegenerative diseases
