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By contrast, the expression of CBS is inducible by dimethyl fumarate (DMF) through nuclear factor erythroid 2-related factor 2 (NRF2) activation and CpG islands DNA hydroxymethylation

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These benefits were associated with a rebalancing of the cytokine milieureducing pro-inflammatory IL-6, IL-1, and TNF- while elevating anti-inflammatory TGF-1mediated by the suppression of the MAPK signaling pathway [76]

[26] [27] They are generally safe but contraindicated with nitrate medications and riociguat, and require caution in men with cardiovascular disease or those taking alpha-blockers

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