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What trials documented: Peaks 2-4 hours after injection Worst during initial dose escalation (weeks 1-6) Significantly improves as subjects adapt Can return temporarily on dose increases Community-reported management strategies: Community-reported starting doses begin around 0.5 mg weekly Self-reported bedtime injection to sleep through peak effects Community sources describe smaller, more frequent meals Avoidance of high-fat foods for 24 hours post-injection is commonly described Anti-nausea medications (ondansetron) reported in severe cases under clinician guidance Diarrhea Frequency: 13% of trial participants Onset: 2-6 hours post-injection Duration: 12-24 hours typically Severity: Usually mild to moderate Diarrhea appears less common with retatrutide compared to semaglutide at maximum doses (30% at 2.4 mg)