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Proc Natl Acad Sci USA (2005) 102(39):1390914
Ipamorelin: synthetic pentapeptide PEPTIDE SEQUENCE CJC-1295 (no DAC): H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser Ipamorelin: Aib-His-D-2-Nal-D-Phe-Lys-NH 2 CHEMICAL STRUCTURE CJC-1295: Ipamorelin: CHEMICAL STRUCTURE CJC-1295 (no DAC): C 152 H 252 N 44 O 42 Ipamorelin: C 38 H 49 N 9 O 5 Mechanism of Action The CJC-1295 (no DAC) + ipamorelin peptide blend stimulates endogenous growth hormone (GH) release by simultaneously activating the growth hormone-releasing hormone receptor (GHRH-R) and the ghrelin/growth hormone secretagogue receptor (GHSR), resulting in synergistic, physiologically pulsatile GH secretion
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Fibroblast activity receives a nudge, so collagen scaffolds gain structure and stay organized
