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Notably, a single administration of semaglutide significantly inhibited the expression of cocaine-induced CPP in animals (Figure 6A), but had no significant effect on the extinction (weakening of an established place preference through repeated unrewarded context exposure) and reinstatement (the re-emergence of that place preference after the extinction and is triggered by a precipitating factor for relapse) of CPP (Figures 6B, 6C)
Interactions with autoimmune medications No significant drug interactions have been identified between GLP-1 receptor agonists and common autoimmune medications, including methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, or biologic DMARDs
110 (42), E4016E4025
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