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Melanotan 1 (afamelanotide) is MC1R-preferential : it is comparatively focused on the pigmentation receptor, which is precisely why its clinically observed effects center on skin darkening and photoprotection rather than on sexual function or appetite

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In rodents there is high expression of GLP-1Rs in the calcitonin-producing C-cells of the thyroid, and activation of these receptors by GLP-1RAs stimulates the adenylate cyclase pathway, leading to upregulation of calcitonin synthesis and, subsequently, hyperplasia and an increased incidence of adenomas (88)