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The Full Hormonal Picture: Progesterone, Testosterone, and the Limits of a Two-Variable Equation The framework built so far has focused primarily on estrogen and GLP-1 receptor agonists as the central players in the menopausal metabolic disruption

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Two residues with shorter side chains (I7 P and A13 P ) in GIP further weakened its binding to GLP-1R, consistent with the distinct cross-reactivity features of GIP and GCG with GLP-1R 5,6