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These conditions include cardiovascular disease (such as coronary artery disease, stroke, life-threatening arrhythmias, congestive heart failure, or untreated hypertension), advanced arteriosclerosis, hyperthyroidism, glaucoma, psychiatric agitation or psychosis, recent or concurrent MAOI therapy (within 14 days), history of drug abuse, pregnancy, breastfeeding, pediatric patients under 16, and concurrent use of other weight-loss medications

And on dosage, most clinical research on glutathione supplementation sits in the 250 to 500 mg range

MicroRNA-195 regulates metabolism in failing myocardium via alterations in sirtuin 3 expression and mitochondrial protein acetylation

Retrieved from Evans, J., Richards, J