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The mechanism of Co-C and Co-O bond cleavage in vitamin B12 during the processes analyzed in this article is schematically shown in Fig

FIGURE 3 FIGURE 4 Causal effect of six cancers on endogenous antioxidants Based on the Bonferroni-corrected threshold, no significant causal association between the six cancers and endogenous antioxidants was found in the reverse MR analysis (Figure 3B)