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At the same time, tissue inhibitors of metalloproteinases (TIMPs) increase across all tested concentrations

Aggravating factors for MTHFR include heavy metals exposure from amalgams, mercury-laced fish, aluminum cookware and occupational hazards as well as a diet high in processed and hydrogenated foods

Moreover, glutamine can be targeted therapeutically, as demonstrated by its ability to repolarize macrophages from an M1 to an M2 phenotype, which can prevent obesity- or diabetes-associated pathology (Ren et al., 2019)

Caffeine 18 is also linked to increased anxiety in genetically susceptible people, another concern with HPA axis dysregulation