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135 Our experiments in rats with Ang IV and with more selective AT 4 -ligands, LVV-H7 and AT416, did not reveal any putative AT 4 /IRAP-mediated vasodilator response neither after systemic nor after renal administration, and also not after AT 1 receptor blockade

[5] [6] For men, obesity contributes to: Reduced testosterone levels : Adipose tissue converts testosterone to oestrogen through aromatase activity, leading to hypogonadism