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5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed
It has been studied for its ability to prevent or reverse liver lesions induced by alcohol consumption
So why on earth is the BOP trying to restrict B12 as methylcobalamin
(See here: Vitamin B12 Deficiency Test) Interruptions in the Methylation Cycle The methylation cycle can be interrupted at various points, either due to nutrient deficiencies or genetic mutations which affect the required enzymes
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