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Further characterisation of the GCG-like family of peptides led to the discovery of an endogenous GLP-1/glucagon co-agonist oxyntomodulin, named for its potent effect on stimulating oxyntic (parietal) cells of the stomach to produce gastric acid
Glycation In addition to oxidative stress, studies have uncovered a causative role for another modification, known as glycation , in the opacification of the lens (Swamy 1987)
It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants
However, in AP/CP there is marked increase in GLP-1R, primarily in PSCs
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