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The majority of patients with a MACE-4 event ( n = 109) were participants in the SURPASS-4 trial investigating a study population with a high cardiovascular risk

Some companies are choosing to provide coverage and others are looking at options and grappling with how they can afford it

Most trials used 3-5g/day

Contraindications: Hypersensitivity Side Effects: CNS Depression (Sedation) & Bradycardia : The most common adverse effects of clonidine are sedation, dry mouth (xerostomia) , fatigue , bradycardia , dizziness, and constipation (Patel and Saadabadi, 2025

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