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Furthermore, animal studies demonstrate that the microbiota in the gut can alter the neurological aspects of depression (103), such as low-grade immune activation (104), the HPA activity (105), altered tryptophan metabolism (106), and neurotrophic factors (107, 108)
That is worth being honest with yourself about, and it is still clinically useful
GSH depletion has been identified as an early-stage event in the pathogenesis of Parkinson's disease, occurring before the loss of dopaminergic neurons becomes clinically apparent
Acknowledgements This work was supported by NIH grant R01 CA79882 to JMS from the National Cancer Institute and by a Predoctoral Fellowship in Pharmacology by Pharmaceutical Research and Manufacturers of America Foundation awarded to Austin M Dulak
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