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Overview of the available GLP-1RAs listed according to their reported half-lives ( t 1/2 ) and the current clinical evidence of their effect in treatment of BAD Here, we review the scarce literature on the use of different GLP-1RAs in BAD treatment and discuss the potential of different GLP-1RAs in the context of their pharmacokinetic profiles, which we speculate may be important determinants of their mode of actions and, thus, pharmacodynamics in BAD

Thus, when the peripheral plasma glucose concentration is 7.6 mM, the interstitial VMH glucose is only 2.5 mM [67]

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