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10 Adverse events 5% in SUSTAIN 5 8,10 AEs occurring in 5% of participants treated with Ozempic in SUSTAIN 5 Incidence of severe hypoglycemia was 1.5% across all placebo-controlled trials 1 Incidence of severe hypoglycemia or blood glucose-confirmed hypoglycemia (% of patients) was 8,10 : 8.3% with Ozempic 0.5 mg + basal insulin MET 10.7% with Ozempic 1 mg + basal insulin MET 5.3% with placebo + basal insulin MET Patients receiving Ozempic in combination with an insulin secretagogue (eg, sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia 1 ADA=American Diabetes Association
(2014) as a weak inhibitor of the voltage-gated proton channel Hv1, which exhibited 20% inhibition at 200 M
The Phase 2 trial data did not report a significant increase in clinically relevant arrhythmias, but this is an area of ongoing safety monitoring.
Abdominal Pain: Gentle physical activity and relaxation techniques may assist in alleviating discomfort
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