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Label warnings to know: Thyroid C-cell tumor warning (avoid if personal/family history of medullary thyroid carcinoma or MEN2) Pancreatitis riskseek immediate care for severe abdominal pain Gallbladder disease Dehydration/acute kidney injury risk with persistent vomiting or diarrhea Drug interactions: Birth control (tirzepatide): Oral contraceptives may be less effective around initiation and each dose increase

Phasing and lifestyle inputs are covered in Supporting Factors below

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Healthcare professionals should maintain vigilance regarding these intersecting risk factors when managing patients on GLP-1 receptor agonists