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TCF7L2 is a possible regulator of GLP-1 receptor expression in human vascular cells Since there was correlation between the expression levels of GLP-1 receptor and TCF7L2 in the aorta in our experiments and it is well known that TCF7L2 is a transcriptional factor of GLP-1 receptor in pancreatic -cells, we hypothesized that TCF7L2 regulates GLP-1 receptor expression in human vascular cells as observed in -cells

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Weight loss medications such as Wegovy, Mounjaro, Saxenda, and Orlistat help reduce appetite, regulate glucose levels, and support weight loss goals

However, no human trial has tested this specific blend, so the combined safety and effect profile is not established