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Individual response depends on mechanism of action, comorbidities, and underlying biology

[29] examined treatment resistance in IIH (defined by authors as composite of indicators including requirement for escalation of medical therapy, progression to surgical intervention, need for CSF diversion procedures, or optic nerve decompression or sheath fenestration)) and noted a trend toward fewer refractory cases with tirzepatide (20.5% risk reduction, RR 0.795, p = 0.019 at 24 months)

However, some people experience headaches, particularly when starting Semaglutide treatments

Sester DP, Brion K, Trieu A, Goodridge HS, Roberts TL, Dunn J, et al