CHICAGO (February 2, 2026) With over 31 million people currently using GLP-1 drugs like Ozempic and Mounjaro, the conversation has shifted from weight loss success stories to serious legal questions
Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]
Our more focused approach, which restricted the intervention to semaglutide, used longitudinal designs with time-to-event analysis, and carefully handled comparators and overlapping populations, may partly explain the higher pooled HR
Presented for research literature review only Chang KC et al