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This concern was related to the action of DPP-4 to cleave a number of bioactive peptides with alanine or proline as the second amino acid from the N-terminal end apart from GLP-1 and GIP, such as neuropeptide Y, gastrin-releasing peptide, substance P, and various chemokines ( Low Risk of Hypoglycemia A consisting finding with DPP-4 inhibition has been its low risk for hypoglycemia
Nov 2000;152(4):353-61
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