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Severe B12 deficiency is widely reported and leads to pernicious anemia since your body needs B12 to make red blood cells, and a deficiency limits its capabilities to build them
Another relatively novel role of NAD + is involvement in forming non-canonical caps on the 5 end of RNA that mark RNA for degradation in eukaryotes 337,338,339
doi: 10.1111/acer.14730 51 GuerrerioALColvinRMSchwartzAKMollestonJPMurrayKFDiehlAet al
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