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Results from a post hoc subgroup analysis of the SURMOUNT-1 study (NCT04184622), published this year [87] , demonstrated that among 32 pathogenic MC4R variant carriers (1.4% of the study population) with a median age of 41.06 years and a BMI 40 kg/m 2 , treatment with tirzepatide for 72 weeks resulted in an 18.3% reduction in body weight from baseline

To determine the circulating cytokine milieu and vascular endothelial activation we next performed an array analysis of anti- and pro-inflammatory cytokines in plasma samples from all groups (Fig

The co-cultures were incubated on an orbital shaker set at a speed of 150 rpm, 30 C, under a light intensity of ~ 20 mol m 2 s 1

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