There are three groups of people who should ensure they have a regular, reliable source of vitamin B12 by supplementing their diet with vitamin B12-fortified foods or B12 supplements: those whove had bariatric surgery (which can sometimes impair absorption), those eating plant-based diets, and the more than a hundred million Americans older than age 50
Younger patients may experience different side effect profiles than older adults
Key takeaways Tirzepatide isnt recommended during pregnancy because human data is inadequate, and animal studies have shown fetal malformations and reduced offspring weight
Regardless of timing, the following general measures may help manage side effects: Eat smaller, more frequent meals rather than large portions Avoid high-fat or spicy foods around the time of injection Stay well hydrated to reduce nausea and support kidney function When to seek urgent medical attention: Contact your GP, trial team, or NHS 111 promptly if you experience severe or persistent abdominal pain (particularly if it radiates to the back), vomiting that prevents you from keeping fluids down, signs of jaundice (yellowing of the skin or eyes), fever, or significantly reduced urine output