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Research is mixed, but a 2025 systematic review reported that microbiome interventions (e.g., probiotics) generally improved body weight, body fat percentage, and metabolic parameters (e.g., lipid levels, glucose metabolism) in people with obesity
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From a bulk purchasing perspective, tirzepatide is currently more readily available than retatrutide through both pharmaceutical and research channels, since tirzepatide already has FDA approval (as Mounjaro for type 2 diabetes and Zepbound for weight management)
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