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doi: 10.1016/S0021-9258(19)36565-2 8 LauJBlochPSchafferLPetterssonISpetzlerJKofoedJet al

To further confirm the involvement of Nrf2, Nrf2 expression was down-regulated by Nrf2 siRNA transfection, which significantly increased the expression of inflammatory factors including IL-6, iNOS, as well as the cartilage matrix degradation factor, MMP13, in chondrocytes treated with metformin

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