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Here, we present new evidence in -cells and primary mouse and human islets demonstrating that, following agonist binding and internalisation, endosomal GLP-1R binds to endoplasmic reticulum (ER)-localised ER-mitochondria membrane contact site (ERMCS) organising factor VAPB to locally engage SPHKAP, an A-kinase anchoring protein (AKAP) whose gene coding variants have been linked to T2D and high BMI risk in genome-wide association studies (GWAS)

J Theor Biol 238:608615 Schmit AR, Ratcliffe NA (1977) The encapsulation of foreign tissue implants in Galleria mellonella larvae

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