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In addition, peripheral (tail) blood collected at time points 30, 60, and 90 min was assayed for glucose and insulin concentrations
Only 5 patients stopped the trial from gastrointestinal side effects and only 5% of the 9mg and 12mg arms had to stop the trial for any adverse events
Importantly, tricyclic antidepressants, especially amitriptyline and nortriptyline, worsen the metabolic profile, increasing insulin resistance, contributing to weight gain and causing hyperglycemia, thereby increasing the risk of diabetes with prolonged use [77]
The body is beginning to adjust to the semaglutide
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