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The most frequently reported side effects involve the gastrointestinal systemnausea occurs in up to 25% of users, while constipation and vomiting appear in smaller percentages

In the STEP 1 trial which studied semaglutide in adults with overweight or obesity, researchers studied body mass composition as a secondary endpoint via DXA in a subpopulation of trial enrollees randomized to treatment or placebo

NICE has not yet issued technology appraisal guidance or clinical guidelines specific to retatrutide, given its investigational status

Limitations: Side Effects and Chronic Use Requirement Semaglutide's most common adverse effects are gastrointestinal