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Since human studies are limited, long-term safety is still being evaluated
For those seeking to optimize longevity, peptides such as Epitalon and MOTS-c have shown promising results in extending cellular lifespan and improving mitochondrial function
However, A plaques in these spaces can lead to reduced expression of AQP4 at the astrocytic end-feet, adversely affecting A efflux with the ISF and exacerbating intraparenchymal A deposition [58, 173, 174]
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