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Depth of evidence is where tesamorelin stands apart: it carries multiple randomized controlled trials and an FDA approval, whereas ipamorelin remains a research compound with primarily preclinical data, and sermorelin sits between them with older clinical history
Studies such as LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide) have shown that these medications may slow the progression of diabetic kidney disease and reduce albuminuria (protein in the urine), which is a marker of kidney damage
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