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Both vitamins are considered safe for long-term use when monitored properly

The additional daily injections, timing requirements (fasted administration for AOD 9604), and cost may not justify whatever incremental benefit exists

Safety Profile and Copper Peptide Side Effects GHK-Cu demonstrates a favorable safety profile with minimal reported adverse effects in most clinical applications

Some research also points to GHK-Cu inhibiting 5-alpha-reductase activity, the enzyme that converts testosterone to follicle-damaging DHT, though this finding is preliminary and far less established than its skin-remodeling effects