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At the beginning of each experiment, mice were equally distributed into experimental groups according to their body weight and body composition

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The BRET signal resulting from ligand stimulation was calculated by subtracting the BRET ratio for the vehicle-treated cells from the ligand-stimulated cells of the same aliquot

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ROS including superoxide (O 2 ), hydroxyl radical (HO ), and hydrogen peroxide (H 2 O 2 ) may cause lipid peroxidation, cell membrane damage, inflammation, and autoimmune diseases (Figure 1)

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