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This profile supports its application in research focused on alternative pain signaling mechanisms, including interactions with endogenous opioid peptides and neurochemical mediators such as substance P
Nagarsheth, N., Wicha, M
There's no published contact-allergy case reports for this ingredient but as with any botanical, a patch test is sensible if you react to plant extracts generally
Patents Battula VL, Andreeff M , Mani SA, Sarkar TR
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