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This method bypasses the digestive system, making it ideal for people who: Have trouble absorbing B12 due to gastrointestinal issues (like Crohns disease or coeliac disease) Are on medications that interfere with B12 absorption (like metformin or anti-acids) Follow vegan or vegetarian diets Have undergone gastric surgery

For another key nutrient in this space, see our guide on magnesium for anxiety and stress, which covers the GABA and parasympathetic pathways that complement what B12 does on the neurotransmitter side

If your provider does not ask what medications you are taking, raise the issue yourself

Expression of CYP4A22 is low in all tissues in which it is found