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TMA results from microbial metabolism of dietary choline, carnitine and trimethylamine N-oxide (TMAO) before being absorbed and N-oxidized into TMAO by hepatic flavin-containing mono-oxygenase 3 (FMO3)
Rapid dose escalation People who increase their dose quickly, skipping steps in the recommended dose schedule , appear more likely to develop skin sensitivity
We used new-user design to mitigate prevalent user bias and confounding associated with the drug itself 55,56
K., Gough, L
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