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However, this does not prove that every symptom during weight loss is caused by toxicant mobilization, and current evidence has not established a unique GLP-1-related toxin release syndrome. Symptoms during GLP-1 treatment are more often explained by recognized medication effects, reduced food or fluid intake, dehydration, constipation, nutrient insufficiency, blood sugar changes, or gallbladder complications

Patients who cannot tolerate dose escalation due to nausea, vomiting, or diarrhea may experience suboptimal outcomes

Anyone who is low in folate (and high in homocysteine) is likely to benefit from a folate supplement

They get directly into your bloodstream and work much faster and more effectively