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In contrast, persistently stabilized NRF2 in response to KEAP1 or NRF2 mutations causes sustained activation of these genes, leading to the accumulation of xCT/SLC7A11, GCLC, and GCLM that cause a depletion of intracellular glutamate (Sayin et al

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In addition, water-soluble Vitamin C contributes to the formation of collagen, a protein plays an vital role in building and supporting many tissues: from bones and cartilage to skin, hair, eyes, gums and blood vessels

10.1186/s13195-021-00810-x Alzheimers Res