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A 2025 systematic review and meta-analysis published in Obesity Reviews analyzed eight randomized controlled trials that included participants with a BMI of 27 or higher (N=2,372) who had been on GLP-1 receptor agonist therapy and then stopped
Regarding hospitalization for heart failure, the HR was 0.83 (95% CI 0.671.04) for those under 65 years of age and 0.62 (95% CI 0.510.76) for those aged 65 years or older ( p interaction = 0.06), 0.72 (95% CI 0.610.84) for those under 75 years and 0.64 (95% CI 0.361.12) for those aged 75 years or older ( p interaction = 0.70), with no evidence of reduced efficacy in older patients
Therefore, the discovery of this parallel GSH-independent mechanism for lipid peroxide scavenging is of great interest for development of ferroptosis-based potential chemotherapeutics
2013;136(Pt 2):37484
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