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Nel 2019 stato avviato il trial FLOW ( Effect of Semaglutide Versus Placebo on the Progression of Renal Impairment in Subjects With Type 2 Diabetes and Chronic Kidney Disease ) [59], che ha reclutato 3508 pazienti al fine di valutare la capacit di semaglutide di ridurre lincidenza dellendpoint primario composito (declino del eGFR 50% rispetto al basale, necessit di dialisi, morte per cause renali, morte per malattia cardiovascolare) rispetto al placebo

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Concurrent application with highly acidic or strongly chelating topical agents-such as concentrated ascorbic-acid serums-may reduce the activity of one or both products because copper ions can catalyze oxidation reactions

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