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consulted for Eli Lilly & Co., and D.H.vR

Three replicates were performed for each FACS experiment and 17,00028,000 cells were eventually included in statistical analysis (Fig

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

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