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We think this is a big deal. The company plans to seek regulatory approval for orforglipron for weight management by the end of this year and for the treatment of type 2 diabetes in 2026

Discard Zepbound if you notice: Cloudiness or haziness in the liquid Particles, flakes, or floating debris Color changes from clear to yellow, brown, or any other tint Cracks or damage to the pen itself The medication has been frozen Room temperature storage exceeded 21 days Youre uncertain about storage conditions When uncertain about whether Zepbound remains safe to use, err on the side of caution and request a replacement

In this context, RWS have confirmed the greater reduction in HbA1c when comparing GLP-1RAs (mainly liraglutide and exenatide-OW) with dapagliflozin 53 but not compared with emapagliflozin 54 or canagliflozin

This means you need to plan your reconstitution timing so that you finish the vial within about four weeks