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The tested animals that were listed in the patent include rats, mice, rabbits, guinea pigs and pigs, as well as a single study in humans
Available from: Accessed on 25/09/2025
Its core pathophysiological characteristics are intricately intertwined with abnormal iron and lipid metabolism, oxidative stress, mitochondrial dysfunction, and neuroinflammation, driving the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) ( Figure 2 )
The The CIR (Cosmetic Ingredient Review) Expert Panel concluded Kojic Acid is safe for use in cosmetic products at concentrations up to 1% and the EU's SCCS (Scientific Committee on Consumer Safety) considers it safe as a skin lightening agent at concentrations up to 0.7%
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